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Optic Nerve Subarachnoid Space Posture Dependency - An MRI Study in Subjects With Normal Tension Glaucoma and Healthy Controls

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dc.contributor.author Kristiansen, Martin
dc.contributor.author Holmlund, Petter
dc.contributor.author Lindén, Christina
dc.contributor.author Eklund, Anders
dc.contributor.author Jóhannesson, Gauti
dc.date.accessioned 2024-04-25T01:05:58Z
dc.date.available 2024-04-25T01:05:58Z
dc.date.issued 2023-12-01
dc.identifier.citation Kristiansen , M , Holmlund , P , Lindén , C , Eklund , A & Jóhannesson , G 2023 , ' Optic Nerve Subarachnoid Space Posture Dependency - An MRI Study in Subjects With Normal Tension Glaucoma and Healthy Controls ' , Investigative ophthalmology & visual science , vol. 64 , no. 15 , pp. 20 . https://doi.org/10.1167/iovs.64.15.20
dc.identifier.issn 0146-0404
dc.identifier.other 214473979
dc.identifier.other 1b24ab93-ae1b-48ab-99a2-7b029be5847e
dc.identifier.other 85179765988
dc.identifier.other 38099734
dc.identifier.uri https://hdl.handle.net/20.500.11815/4839
dc.description.abstract PURPOSE: The purpose of this study was to examine the differences of optic nerve subarachnoid space (ONSAS) volume in patients with normal tension glaucoma (NTG) and healthy controls in different body positions. METHODS: Eight patients with NTG and seven healthy controls underwent magnetic resonance imaging (MRI) examinations in head up tilt (HUT) +11 degrees and head down tilt (HDT) -5 degrees positions according to a randomized protocol determining the starting position. The ONSAS volume in both body positions was measured and compared between the two groups. The results were analyzed using a generalized linear model. RESULTS: Between HDT and HUT, the postural ONSAS volume change was dependent on starting position (P < 0.001) and group (P = 0.003, NTG versus healthy). A subgroup analysis of those that were randomized to HUT examination first, coming directly from an upright position, showed that the patients with NTG had significantly larger positional ONSAS volume changes compared to the healthy controls; 121 ± 22 µL vs. 65 ± 37 µL (P = 0.049). Analysis of the ONSAS volume distribution showed different profiles for patients with NTG and healthy controls. CONCLUSIONS: There was a significant difference in ONSAS volume change between patients with NTG and healthy subjects when subjected to posture changes, specifically when going from upright to head-down posture. This indicates that patients with NTG had been exposed to a lower ONSAS pressure when they came from the upright posture, which suggests an increased translaminar pressure difference in upright position. This may support the theory that NTG has a dysfunction in an occlusion mechanism of the optic nerve sheath that could cause abnormally negative ONSAS pressures in upright posture.
dc.format.extent 1
dc.format.extent 1032280
dc.format.extent 20
dc.language.iso en
dc.relation.ispartofseries Investigative ophthalmology & visual science; 64(15)
dc.rights info:eu-repo/semantics/openAccess
dc.subject Humans
dc.subject Low Tension Glaucoma/diagnosis
dc.subject Magnetic Resonance Imaging
dc.subject Optic Nerve
dc.subject Posture
dc.subject Subarachnoid Space/diagnostic imaging
dc.title Optic Nerve Subarachnoid Space Posture Dependency - An MRI Study in Subjects With Normal Tension Glaucoma and Healthy Controls
dc.type /dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article
dc.description.version Peer reviewed
dc.identifier.doi 10.1167/iovs.64.15.20
dc.relation.url http://www.scopus.com/inward/record.url?scp=85179765988&partnerID=8YFLogxK
dc.contributor.department Faculty of Medicine


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