Titill: | Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study |
Höfundur: |
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Útgáfa: | 2018-10-11 |
Tungumál: | Enska |
Umfang: | 1101-1109 |
Háskóli/Stofnun: | Háskóli Íslands University of Iceland Háskólinn í Reykjavík Reykjavik University |
Svið: | Heilbrigðisvísindasvið (HÍ) School of Health Sciences (UI) Viðskiptadeild (HR) School of Business (RU) |
Deild: | Læknadeild (HÍ) Faculty of Medicine (UI) Lífvísindasetur (HÍ) Biomedical Center (UI) |
Birtist í: | Sleep and Breathing;22(4) |
ISSN: | 1520-9512 1522-1709 (eISSN) |
DOI: | 10.1007/s11325-018-1731-6 |
Efnisorð: | Obstructive sleep apnea; Positive airway pressure; Obesity; Chitinase-3-like protein 1; Chitotriosidase; Kæfisvefn; Offita |
URI: | https://hdl.handle.net/20.500.11815/1270 |
Tilvitnun:Teitsdottir, U. D., Arnardottir, E. S., Bjornsdottir, E., Gislason, T., & Petersen, P. H. (2018). Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study. Sleep and Breathing, 22(4), 1101-1109. doi:10.1007/s11325-018-1731-6
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Útdráttur:Purpose The inflammatory markers chitinase-3-like protein 1 (CHI3L1) and chitotriosidase (CHIT1) have both been associated
with cardiovascular complications. The aim of this preliminary observational study was to assess the roles and interaction of
obstructive sleep apnea (OSA) severity and body mass index (BMI) with plasma CHI3L1 levels and CHIT1 activity in patients
with moderate to severe OSA. The second aim was to assess the roles and interaction of positive airway pressure (PAP) treatment
and BMI on the expression of the same proteins.
Methods The study included 97 OSA patients with an apnea–hypopnea index (AHI) ≥ 15 and full usage of PAP treatment after
4 months. Plasma CHI3L1 levels and CHIT1 activity were measured before and after treatment.
Results Multiple linear regression analysis demonstrated an independent association of BMI on CHI3L1 levels (p < 0.05) but not
on CHIT1 activity. The OSA severity markers (AHI and oxygen desaturation index) did not independently or in interaction with
BMI levels associate with CHI3L1 levels or with CHIT1 activity (p > 0.05). A two-way repeated measures ANOVA revealed a
significant interaction between PAP treatment effect (before vs. after) and BMI groups (< 35 kg/m2 vs. ≥ 35 kg/m2
) on CHI3L1
levels (p = 0.03) but not on CHIT1 activity (p = 0.98).
Conclusions Obesity independently associated with CHI3L1 levels. Association between OSA severity and CHI3L1 levels or
CHIT1 activity (independent of or dependent on obesity level) could not be confirmed. Howe
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Athugasemdir:Publisher's version (útgefin grein)
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Leyfi:This article is distributed under the terms of the Creative
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